CD8a Antibody [2.43] (APC)

Product Specifications

Background

The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b. CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells.

NCBI Gene ID

12525

Swiss Prot

P01731

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

2.43

Conjugation

APC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2b

Specificity

The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen.

Symbol

Cd8a

NCBI Official Name

CD8 antigen, alpha chain

NCBI Organism

Mus musculus

Background Reference 01

Hirji, N., Lin, T. J., Bissonnette, E., Belosevic, M., Befus, A. D. (1998) . Mechanisms of macrophage stimulation through CD8: macrophage CD8alpha and CD8-beta induce nitric oxide production and associated killing of the parasite Leishmania major.The Journal of Immunology,160 (12), 6004-6011.

Background Reference 02

Hirji, N., Lin, T. J., Befus, A. D. (1997) . A novel CD8 molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production.The Journal of Immunology,158 (4), 1833-1840.

Background Reference 03

Torres‐Nagel, N., Kraus, E., Brown, M. H., Tiefenthaler, G., Mitnacht, R., Williams, A. F., Hnig, T. (1992) . Differential thymus dependence of rat CD8 isoform expression.European journal of immunology,22 (11), 2841-2848.