CD27 Antibody [LG.3A10]

Product Specifications

Background

The LG.3A10 monoclonal antibody binds to CD27, 45kDA molecule in the Tumor Necrosis Factor Receptor (TNFR) superfamily. It is expressed on memory B cells, NK cells, mature T cells, and a subset of thymocytes. Cd27 is involved in the interactions between B and T cells through its ligand CD70. The LG.3A10 antibody is cross-reactive with human, mouse and rat CD27.

NCBI Gene ID

21940

Swiss Prot

P41272

Host

Hamster

Reactivity

Human, Mouse

Clonality

Monoclonal

Clone

LG.3A10

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology, Apoptosis

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Armenian Hamster IgG

Specificity

The LG.3A10 monoclonal antibody binds to CD27, 45kDA molecule in the Tumor Necrosis Factor Receptor (TNFR) superfamily.

Symbol

Cd27

NCBI Official Name

CD27 antigen

NCBI Organism

Mus musculus

Background Reference 01

Tesselaar, K., Xiao, Y., Arens, R., van Schijndel, G. M., Schuurhuis, D. H., Mebius, R. E., ... van Lier, R. A. (2003) . Expression of the murine CD27 ligand CD70 in vitro and in vivo.The journal of immunology,170 (1), 33-40.

Background Reference 02

Lee, E. M., Hurh, S., Cho, B., Oh, K. H., Kim, S. U., Surh, C. D., ... Ahn, C. (2013) . CD70-CD27 ligation between neural stem cells and CD4+ T cells induces Fas-FasL-mediated T cell death.Stem cell research therapy,4 (3), 56.

Background Reference 03

Gravestein, L. A., Nieland, J. D., Kruisbeek, A. M., Borst, J. (1995) . Novel mAbs reveal potent co-stimulatory activity of murine CD27.International immunology,7 (4), 551-557.