CD27 Antibody [O323] (APC-Cy7)
Product Specifications
Background
The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells. CD27 is upregulated by T lymphocytes stimulation, and binds to CD70, enhancing the interaction between T and B lymphocytes. CD27 is a marker of memory B cells.
NCBI Gene ID
939
Swiss Prot
P26842
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
O323
Conjugation
APC-Cy7
Type
Primary Antibodies
Field of Research
Immunology, Apoptosis
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-628
Fragment
Mouse IgG1, kappa
Specificity
The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells.
Symbol
CD27
NCBI Official Name
CD27 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Hendriks, J., Xiao, Y., Borst, J. (2003) . CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.The Journal of experimental medicine,198 (9), 1369-1380.
Background Reference 02
Sakanishi, T., Yagita, H. (2010) . Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice.Biochemical and biophysical research communications,393 (4), 829-835.
Background Reference 03
Gravestein, L. A., Nieland, J. D., Kruisbeek, A. M., Borst, J. (1995) . Novel mAbs reveal potent co-stimulatory activity of murine CD27.International immunology,7 (4), 551-557.
Other Product Names
T14, S152, Tp55, TNFRSF7, S152. LPFS2, CD27
Tested Applications
Flow
Physical Properties
Liquid
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