CD86 Antibody [PO3.1] (PE)

Product Specifications

Background

The PO3.1 monoclonal antibody specifically reacts with CD86, also known as B7-2, a surface 80 kDa receptor and member of the B7 family. CD86 is a costimulatory molecule, expressed on B and T cells, dendritic cells, astrocytes, macrophages, Langerhans cells, and at a low level in newly explanted B and T lymphocytes. CD86 expression on B lymphocytes is upregulated by B-Cell Receptor complex, CD40 and certain cytokine receptors. CD80 (B7-1) and CD 86 (B7-2) are receptors for CD28 and CTLA-4, on the surface of T lymphocytes, enhancing the interactions between B and T cells.

NCBI Gene ID

12524

Swiss Prot

P42082

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

PO3.1

Conjugation

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2b, kappa

Specificity

The PO3.1 monoclonal antibody specifically reacts with CD86, also known as B7-2, a surface 80 kDa receptor and member of the B7 family.

Symbol

Cd86

NCBI Official Name

CD86 antigen

NCBI Organism

Mus musculus

Background Reference 01

McMichael, A. J. (1987) .Leucocyte typing III: white cell differentiation antigens. Oxford University Press, USA.

Background Reference 02

Lankester, A. C., van Schijndel, G. M., Cordell, J. L., van Noesel, C. J., van Lier, R. A. (1994) . CD5 is associated with the human B cell antigen receptor complex.European journal of immunology,24 (4), 812-816.

Background Reference 03

Kap, Y. S., van Meurs, M., van Driel, N., Koopman, G., Melief, M. J., Brok, H. P., ... A't Hart, B. (2009) . A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.Journal of Histochemistry Cytochemistry,57 (12), 1159-1167.