CD66b Antibody [G10F5] (FITC)

Product Specifications

Background

The G10F5 monoclonal antibody specifically reacts with human CD66b, a 100kDa glycosylphosphatidylinositol (GPI) linked protein in the granulocyte-specific activation family. CD66b is expressed on granulocytes, neutrophils, and eosinophils. It is reported that this molecule plays a role in regulating neutrophil activation and cellular adhesion. It was previously classified as CD67, but renamed CD66b in the Fifth HLDA Workshop.

NCBI Gene ID

1088

Swiss Prot

P31997

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

G10F5

Conjugation

FITC

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgM, kappa

Specificity

The G10F5 monoclonal antibody specifically reacts with human CD66b, a 100kDa glycosylphosphatidylinositol (GPI) linked protein in the granulocyte-specific activation family.

Symbol

CEACAM8

NCBI Official Name

Carcinoembryonic antigen-related cell adhesion molecule 8

NCBI Organism

Homo sapiens

Background Reference 01

Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

Background Reference 02

Lund-Johansen, F. R. I. D. T. J. O. F., Olweus, J. O. H. A. N. N. A., Horejsi, V. A. C. L. A. V., Skubitz, K. M., Thompson, J. S., Vilella, R., Symington, F. W. (1992) . Activation of human phagocytes through carbohydrate antigens (CD15, sialyl-CD15, CDw17, and CDw65) .The Journal of Immunology,148 (10), 3221-3229.

Background Reference 03

Schmidt, T., Zndorf, J., Grger, T., Brandenburg, K., Reiners, A. L., Zinserling, J., Schnitzler, N. (2012) . CD66b overexpression and homotypic aggregation of human peripheral blood neutrophils after activation by a gram-positive stimulus.Journal of leukocyte biology,91 (5), 791-802.