CD16 Antibody [3G8] (FITC)

Product Specifications

Background

The 3G8 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII) . CD16 is expressed on granulocytes, monocytes, macrophages, and NK cells and plays a role in NK activation and signal transduction. CD16 is expressed as either CD16a or CD16b. CD16a is a polypeptide-anchored transmembrane protein and CD16b is a glycosylphosphatidylinositol (GPI) -anchored protein that is expressed exclusively on neutrophils.

NCBI Gene ID

2214

Swiss Prot

P08637

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

3G8

Conjugation

FITC

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The 3G8 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII) .

Symbol

FCGR3A

NCBI Official Name

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

NCBI Organism

Homo sapiens

Background Reference 01

Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.

Background Reference 02

Hayakawa, Y., Huntington, N. D., Nutt, S. L., Smyth, M. J. (2006) . Functional subsets of mouse natural killer cells.Immunological reviews,214 (1), 47-55.

Background Reference 03

Tittarelli, A., Mendoza-Naranjo, A., Faras, M., Guerrero, I., Ihara, F., Wennerberg, E., ... Salazar-Onfray, F. (2014) . Gap Junction Intercellular Communications Regulate NK Cell Activation and Modulate NK Cytotoxic Capacity.The Journal of Immunology,192 (3), 1313-1319.