CD16 Antibody [2.4G2] (FITC)
Product Specifications
Background
The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc gamma III) and CD 32 (Fc gamma II) . CD16 and CD32 are low affinity receptors for the IgG Fc domain and are expressed by B lymphocytes, NK cells, kupffer cells, mast cells, monocytes, macrophages, granulocytes, immature thymocytes, neutrophils, and some activated mature T cells.The 2.4G2 antibody blocks the binding of immunoglobulins to CD16 and CD32, and possibly to Fc gamma I receptor.
NCBI Gene ID
14131
Swiss Prot
P08508
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
2.4G2
Conjugation
FITC
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-578
Fragment
Rat IgG2b
Specificity
The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc gamma III) and CD 32 (Fc gamma II) .
Symbol
Fcgr3
NCBI Official Name
Fc receptor, IgG, low affinity III
NCBI Organism
Mus musculus
Background Reference 01
Choi, E. I., Wang, R., Peterson, L., Letvin, N. L., Reimann, K. A. (2008) . Use of an anti‐CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques.Immunology,124 (2), 215-222.
Background Reference 02
Perussia, B. I. C. E., Trinchieri, G. I. O. R. G. I. O. (1984) . Antibody 3G8, specific for the human neutrophil Fc receptor, reacts with natural killer cells.The Journal of Immunology,132 (3), 1410-1415.
Background Reference 03
Vossebeld, P. J., Homburg, C. H., Roos, D., Verhoeven, A. J. (1997) . The anti-Fc-gamma RIII mAb 3G8 induces neutrophil activation via a cooperative action of Fc-gamma RIIIb and Fc-gamma RIIa.The international journal of biochemistry cell biology,29 (3), 465-473.
Other Product Names
Fcgr3, Fcgr3
Tested Applications
Flow
Physical Properties
Liquid
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