What is the catalog number for CD16 Antibody [CB16] (FITC)?

The catalog number for CD16 Antibody [CB16] (FITC) is 76-570.

What sizes are available for CD16 Antibody [CB16] (FITC)?

CD16 Antibody [CB16] (FITC) is available in the following size(s): 100 Tests.

Is CD16 Antibody [CB16] (FITC) in stock?

CD16 Antibody [CB16] (FITC) is currently made to order / not held in immediate stock. Contact us for lead time.

CD16 Antibody [CB16] (FITC)

Product Specifications

Background

The CB16 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII) . CD16 is expressed on granulocytes, monocytes, macrophages, and NK cells and plays a role in NK activation and signal transduction. CD16 is expressed as either CD16a or CD16b. CD16a is a polypeptide-anchored transmembrane protein and CD16b is a glycosylphosphatidylinositol (GPI) -anchored protein that is expressed exclusively on neutrophils.

NCBI Gene ID

2214

Swiss Prot

P08637

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

CB16

Conjugation

FITC

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The CB16 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII) .

Symbol

FCGR3A

NCBI Official Name

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

NCBI Organism

Homo sapiens

Background Reference 01

Araujo-Jorge, T. A. N. I. A., Rivera, M. T., el Bouhdidi, A. Y. A. C. H. I., Daron, M. A. R. C., Carlier, Y. (1993) . An Fc gamma RII-, Fc gamma RIII-specific monoclonal antibody (2.4 G2) decreases acute Trypanosoma cruzi infection in mice.Infection and immunity,61 (11), 4925-4928.

Background Reference 02

Jensen, W. A., Marschner, S., Ott, V. L., Cambier, J. C. (2001) . FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization.Biochemical Society Transactions,29 (Pt 6), 840-846.

Background Reference 03

Vremec, D., Zorbas, M., Scollay, R., Saunders, D. J., Ardavin, C. F., Wu, L., Shortman, K. (1992) . The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.The Journal of experimental medicine,176 (1), 47-58.