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CD25 Antibody [BC96] (APC)

Product Specifications

Background

The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor alpha (IL-2R alpha, also known as CD25) . CD25 is expressed by the early progenitors of T and B lymphocytes lineage, and by activated mature T and B lymphocytes. CD25 is a low affinity interleukin-2 receptor, but its association with the IL-2 receptor beta chain (CD122) and the common gamma chain (CD 132) results in a high affinity IL-2R complex. CD25 plays an important role in B and T cell proliferation, differentiation, and activation.

NCBI Gene ID

3559

Swiss Prot

P01589

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

BC96

Conjugation

APC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=76-505

Fragment

Mouse IgG1, kappa

Specificity

The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor alpha (IL-2R alpha, also known as CD25) .

Symbol

IL2RA

NCBI Official Name

Interleukin 2 receptor, alpha

NCBI Organism

Homo sapiens

Background Reference 01

Schlossman, S., L. Bloumsell, et al. eds (1995) . Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York

Background Reference 02

Zhang, B., Zhang, X., Tang, F. L., Zhu, L. P., Liu, Y., Lipsky, P. E. (2008) . Clinical significance of increased CD4+ CD25 Foxp3+ T cells in patients with new-onset systemic lupus erythematosus.Annals of the rheumatic diseases,67 (7), 1037-1040.

Background Reference 03

Chapel, A., Bensussan, A., Vilmer, E., Dormont, D. (1992) . Differential human immunodeficiency virus expression in CD4+ cloned lymphocytes: from viral latency to replication.Journal of virology,66 (6), 3966-3970.

Other Product Names

P55, CD25, IL2R, TCGFR, IDDM10, IL2RA

Tested Applications

Flow

Physical Properties

Liquid

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