CD45RO Antibody [UCHL1] (PerCP-Cy5.5)

Product Specifications

Background

The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45. CD45RO is a transmembrane glycoprotein with tyrosine phosphatase activity and is expressed by majority of thymocytes, monocytes, granulocytes, and activated memory T lymphocytes. The subsets of peripheral T lymphocytes can be discriminated by using the CD45RO and CD45RA expressing cells.

NCBI Gene ID

5788

Swiss Prot

P08575

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

UCHL1

Conjugation

PerCP-Cy5.5

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

MouseIgG2a, kappa

Specificity

The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45.

Symbol

PTPRC

NCBI Official Name

Protein tyrosine phosphatase, receptor type, C

NCBI Organism

Homo sapiens

Background Reference 01

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Background Reference 02

Akbar, A. N., Terry, L., Timms, A., Beverley, P. C., Janossy, G. (1988) . Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.The Journal of Immunology,140 (7), 2171-2178.

Background Reference 03

Smith, S. H., Brown, M. H., Rowe, D., Callard, R. E., Beverley, P. C. (1986) . Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.Immunology,58 (1), 63.