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CD45RO Antibody [UCHL1] (PE)

Product Specifications

Background

The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45. CD45RO is a transmembrane glycoprotein with tyrosine phosphatase activity and is expressed by majority of thymocytes, monocytes, granulocytes, and activated memory T lymphocytes. The subsets of peripheral T lymphocytes can be discriminated by using the CD45RO and CD45RA expressing cells.

NCBI Gene ID

5788

Swiss Prot

P08575

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

UCHL1

Conjugation

PE

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG2a, kappa

Specificity

The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45.

Symbol

PTPRC

NCBI Official Name

Protein tyrosine phosphatase, receptor type, C

NCBI Organism

Homo sapiens

Background Reference 01

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Background Reference 02

Akbar, A. N., Terry, L., Timms, A., Beverley, P. C., Janossy, G. (1988) . Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.The Journal of Immunology,140 (7), 2171-2178.

Background Reference 03

Smith, S. H., Brown, M. H., Rowe, D., Callard, R. E., Beverley, P. C. (1986) . Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.Immunology,58 (1), 63.

Other Product Names

LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180, PTPRC

Tested Applications

Flow

Physical Properties

Liquid

Frequently Asked Questions

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