CD64 Antibody [10.1]
Product Specifications
Background
The 10.1 monoclonal antibody specifically reacts with human CD64, a 75kDA type I transmembrane glycoprotein that is the high affinity receptor for IgG. CD64 is expressed on macrophages and dendritic cells and is involved in antibody-dependent cellular toxicity, cytokine release phagocytosis, and endocytosis. The 10.1 antibody is reported to recognize the EC3 epitope of CD64.
NCBI Gene ID
2209
Swiss Prot
P12314
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
10.1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-439
Fragment
Mouse IgG1, kappa
Specificity
The 15.2 antibody reacts with the 85-110 kDa intracellular adhesion molecule-1 (ICAM-1), a member of the Ig superfamily which acts as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1) .
Symbol
FCGR1A
NCBI Official Name
Fc fragment of IgG, high affinity Ia, receptor
NCBI Organism
Homo sapiens
Background Reference 01
Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
Background Reference 02
Dougherty, G. J., Selvendran, Y., Murdoch, S., Palmer, D. G., Hogg, N. (1987) . The human mononuclear phagocyte high‐affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1.European journal of immunology,17 (10), 1453-1459.
Background Reference 03
Indik, Z. K., Hunter, S., Huang, M. M., Pan, X. Q., Chien, P., Kelly, C., ... Schreiber, A. D. (1994) . The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.Experimental hematology,22 (7), 599-606.
Other Product Names
CD64, FCRI, CD64A, IGFR1, FCGR1A
Tested Applications
Flow, Functional Assays, IHC
Physical Properties
Liquid
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