CD54 Antibody [15.2] (APC)
Product Specifications
Background
The 15.2 antibody reacts with the 85-110 kDa intracellular adhesion molecule-1 (ICAM-1), a member of the Ig superfamily which acts as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1) . ICAM-1 is also known CD 54 and is expressed on non-hematopoietic cells of vascular endothelial, thymic epithelial, fibroblasts lineages, and on hematopoietic cells like macrophages, mitogen-stimulated T-lymphoblasts, dendritic cells in tonsils, lymph nodes and Peyer’s patches, and germinal center B cells.Inflammatory mediators (IL-1, TNF, IFN-gamma) enhance the production of ICAM-1 on fibroblasts and endothelial cells within few hours. Thus, ICAM-1 seems to be the marker of inflammatory reactions.
NCBI Gene ID
3383
Swiss Prot
P05362
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
15.2
Conjugation
APC
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG1
Specificity
The 15.2 antibody reacts with the 85-110 kDa intracellular adhesion molecule-1 (ICAM-1), a member of the Ig superfamily which acts as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1) .
Symbol
ICAM1
NCBI Official Name
Intercellular adhesion molecule 1
NCBI Organism
Homo sapiens
Background Reference 01
Bhattacharya, A. L. O. K., Dorf, M. E., Springer, T. A. (1981) . A shared alloantigenic determinant on Ia antigens encoded by the IA and IE subregions: evidence for I region gene duplication. The Journal of Immunology,127 (6), 2488-2495.
Background Reference 02
Mendiratta, S. K., Singh, N., Bal, V., Rath, S. (1996) . Analysis of T-cell hybridomas with an unusual MHC class II-dependent ligand specificity.Immunology,89 (2), 238-244.
Background Reference 03
Unternaehrer, J. J., Chow, A., Pypaert, M., Inaba, K., Mellman, I. (2007) . The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface.Proceedings of the National Academy of Sciences,104 (1), 234-239.
Other Product Names
BB2, CD54, P3.58, ICAM1
Tested Applications
Flow
Physical Properties
Liquid
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