What is the catalog number for CD54 Antibody [15.2]?

The catalog number for CD54 Antibody [15.2] is 76-430.

What sizes are available for CD54 Antibody [15.2]?

CD54 Antibody [15.2] is available in the following size(s): 0.1 mg.

Is CD54 Antibody [15.2] in stock?

CD54 Antibody [15.2] is currently made to order / not held in immediate stock. Contact us for lead time.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

CD54 Antibody [15.2]

Product Specifications

Background

The 15.2 antibody reacts with the 85-110 kDa intracellular adhesion molecule-1 (ICAM-1), a member of the Ig superfamily which acts as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1) . ICAM-1 is also known CD 54 and is expressed on non-hematopoietic cells of vascular endothelial, thymic epithelial, fibroblasts lineages, and on hematopoietic cells like macrophages, mitogen-stimulated T-lymphoblasts, dendritic cells in tonsils, lymph nodes and Peyer’s patches, and germinal center B cells.Inflammatory mediators (IL-1, TNF, IFN-gamma) enhance the production of ICAM-1 on fibroblasts and endothelial cells within few hours. Thus, ICAM-1 seems to be the marker of inflammatory reactions.

NCBI Gene ID

3383

Swiss Prot

P05362

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

15.2

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Mouse IgG1

Specificity

Symbol

ICAM1

NCBI Official Name

Intercellular adhesion molecule 1

NCBI Organism

Homo sapiens

Background Reference 01

Bhattacharya, A. L. O. K., Dorf, M. E., Springer, T. A. (1981) . A shared alloantigenic determinant on Ia antigens encoded by the IA and IE subregions: evidence for I region gene duplication. The Journal of Immunology,127 (6), 2488-2495.

Background Reference 02

Mendiratta, S. K., Singh, N., Bal, V., Rath, S. (1996) . Analysis of T-cell hybridomas with an unusual MHC class II-dependent ligand specificity.Immunology,89 (2), 238-244.

Background Reference 03

Unternaehrer, J. J., Chow, A., Pypaert, M., Inaba, K., Mellman, I. (2007) . The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface.Proceedings of the National Academy of Sciences,104 (1), 234-239.