CD44 Antibody [IM7]

Product Specifications

Background

The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24) . CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.

NCBI Gene ID

960;12505

Swiss Prot

P16070; P15379

Host

Rat

Reactivity

Human, Mouse

Clonality

Monoclonal

Clone

IM7

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology, Stem Cell

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2b, kappa

Specificity

The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24) .

Symbol

CD44

NCBI Official Name

CD44 molecule (Indian blood group)

NCBI Organism

Homo sapiens; Mus musculus

Background Reference 01

Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., Trotter, J. (1982) . Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues.Immunogenetics,15 (3), 299-312.

Background Reference 02

Lesley, J., Trowbridge, I. S. (1982) . Genetic characterization of a polymorphic murine cell-surface glycoprotein.Immunogenetics,15 (3), 313-320.

Background Reference 03

Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., Naor, D. (1999) . CD44 involvement in experimental collagen-induced arthritis (CIA) .Journal of autoimmunity,13 (1), 39-47.