CD14 Antibody [Sa2-8] (FITC)
Product Specifications
Background
The Sa2-8 monoclonal antibody specifically reacts with mouse CD14, a cell surface anchored glycoprotein that is primarily expressed on macrophages and is secreted in certain conditions. CD14 associates with LPS and LBP to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The Sa2-8 antibody exhibits a weak antagonistic activate in relation to TNF alpha production and NF-kappa B activation.
NCBI Gene ID
929
Swiss Prot
P08571
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
Sa2-8
Conjugation
FITC
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-397
Fragment
Rat IgG2a, kappa
Specificity
The Sa2-8 monoclonal antibody specifically reacts with mouse CD14, a cell surface anchored glycoprotein that is primarily expressed on macrophages and is secreted in certain conditions.
Symbol
CD14
NCBI Official Name
CD14 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Akashi, S., Saitoh, S. I., Wakabayashi, Y., Kikuchi, T., Takamura, N., Nagai, Y., ... Miyake, K. (2003) . Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2 Higher Affinity than That with MD-2 or CD14.The Journal of experimental medicine,198 (7), 1035-1042.
Background Reference 02
Oliva, C., Turnbough, C. L., Kearney, J. F. (2009) . CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages.Proceedings of the National Academy of Sciences,106 (33), 13957-13962.
Other Product Names
CD14, CD14
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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