CD4 Antibody [RM4-5] (APC-Cy7)
Product Specifications
Background
The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells. CD4 binds to the major histocompatibility complex class II (MHC class II) and enhances T lymphocyte development and mature T cells functions. In T lymphocytes, CD4 binds to the cytoplasmic tail of enzyme tyrosine kinase (p56lck) .Binding of RM4-5 is blocked by the anti-mouse CD4 clone GK1.5.
NCBI Gene ID
12504
Swiss Prot
P06332
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
RM4-5
Conjugation
APC-Cy7
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Rat IgG2a, kappa
Specificity
The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells.
Symbol
Cd4
NCBI Official Name
CD4 antigen
NCBI Organism
Mus musculus
Background Reference 01
Shevach, E. M. (2000) . Regulatory T cells in autoimmmunity*.Annual review of immunology,18 (1), 423-449.
Background Reference 02
Wu, L., Scollay, R., Egerton, M., Pearse, M., Spangrude, G. J., Shortman, K. (1991) . CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus.
Background Reference 03
Bliss, S. K., Bliss, S. P., Beiting, D. P., Alcaraz, A., Appleton, J. A. (2007) . IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.The Journal of Immunology,178 (12), 7974-7983.
Other Product Names
L3T4, Ly-4, Cd4
Tested Applications
Flow
Physical Properties
Liquid
Frequently Asked Questions
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