CD4 Antibody [GK1.5] (PE)
Product Specifications
Background
The GK1.5 monoclonal antibody specifically binds with the mouse CD4 molecule, also known as L3T4, a 55 kDa differentiation antigen which binds to the MHC class II. CD4 is expressed on most thymocytes, a subpopulation of mature T lymphocytes, dendritic cells, pluripotent hematopoietic stem cells, B cell precursors, and lymphoid precursors inside the thymus. It is also expressed on the mouse egg cell membrane, enhancing adhesion to MHC class II bearing sperm. By interaction with MHC class II on the surface of APC, CD4 initiates the development of T lymphocytes and helps the optimum functioning of mature T lymphocytes. The binding of the GK1.5 antibody blocks the binding of the Anti-Mouse CD4 RM4-5 antibody.
NCBI Gene ID
12504
Swiss Prot
P06332
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
GK1.5
Conjugation
PE
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-342
Fragment
Rat IgG2b, kappa
Specificity
The GK1.5 monoclonal antibody specifically binds with the mouse CD4 molecule, also known as L3T4, a 55 kDa differentiation antigen which binds to the MHC class II.
Symbol
Cd4
NCBI Official Name
CD4 antigen
NCBI Organism
Mus musculus
Background Reference 01
Dialynas, D. P., Quan, Z. S., Wall, K. A., Pierres, A., Quintans, J., Loken, M. R., ... Fitch, F. W. (1983) . Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1. 5: similarity of L3T4 to the human Leu-3/T4 molecule.The Journal of Immunology,131 (5), 2445-2451.
Background Reference 02
Bosselut, R., Zhang, W., Ashe, J. M., Kopacz, J. L., Samelson, L. E., Singer, A. (1999) . Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction.The Journal of experimental medicine,190 (10), 1517-1526.
Background Reference 03
Ghobrial, R. R., Boublik, M., Winn, H. J., Auchincloss Jr, H. (1989) . In Vivo use of monoclonal antibodies against murine T cell antigens.Clinical immunology and immunopathology,52 (3), 486-506.
Other Product Names
L3T4, Ly-4, Cd4
Tested Applications
Flow
Physical Properties
Liquid
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