CD4 Antibody [OKT4] (APC)

Product Specifications

Background

The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV) . CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II) . The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.

NCBI Gene ID

920

Swiss Prot

P01730

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

OKT4

Conjugation

APC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG2b, kappa

Specificity

The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV) .

Symbol

CD4

NCBI Official Name

CD4 molecule

NCBI Organism

Homo sapiens

Background Reference 01

Reinherz, E. L., Kung, P. C., Goldstein, G., Schlossman, S. F. (1979) . Separation of functional subsets of human T cells by a monoclonal antibody.Proceedings of the National Academy of Sciences,76 (8), 4061-4065.

Background Reference 02

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Background Reference 03

Bour, S. T. E. P. H. A. N. E., Boulerice, F. R. A. N. C. O. I. S., Wainberg, M. A. (1991) . Inhibition of gp160 and CD4 maturation in U937 cells after both defective and productive infections by human immunodeficiency virus type 1.Journal of virology,65 (12), 6387-6396.