CD73 Antibody [AD2] (APC)
Product Specifications
Background
The AD2 monoclonal antibody specifically reacts with human CD73 (ecto-5’-nucleotidase), a 70 kDA glycosyl phosphatidylinositol (GPI) -anchored glycoprotein. CD73 catalyzes the dephosphorylation of adenosine monophosphate (AMP) to adenosine and is expressed on subsets of B, T, dendritic, endothelial, and mesenchymal stem cells. It is also involved in the adhesion of lymphocytes to endothelium and T cell activation.
NCBI Gene ID
4907
Swiss Prot
P21589
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
AD2
Conjugation
APC
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-312
Fragment
Mouse IgG1, kappa
Specificity
The AD2 monoclonal antibody specifically reacts with human CD73 (ecto-5’-nucleotidase), a 70 kDA glycosyl phosphatidylinositol (GPI) -anchored glycoprotein.
Symbol
NT5E
NCBI Official Name
5'-nucleotidase, ecto (CD73)
NCBI Organism
Homo sapiens
Background Reference 01
Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
Background Reference 02
Nakamura, T., Kubagawa, H., Ohno, T., Cooper, M. D. (1993) . Characterization of an IgM Fc-binding receptor on human T cells.The Journal of Immunology,151 (12), 6933-6941.
Background Reference 03
Alam, M. S., Kurtz, C. C., Rowlett, R. M., Reuter, B. K., Wiznerowicz, E., Das, S., ... Ernst, P. B. (2009) . CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice.Journal of Infectious Diseases,199 (4), 494-504.
Other Product Names
NT, eN, NT5, NTE, eNT, CD73, E5NT, CALJA, NT5E
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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