CD3 Antibody [SK7] (APC)

Product Specifications

Background

The SK7 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains gamma, delta, and epsilon chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. The SK7 antibody is reported to have a mitogenic effect on the majority of peripheral blood T cells in the presence of functional monocytes.

NCBI Gene ID

916

Swiss Prot

P07766

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

SK7

Conjugation

APC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The SK7 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex.

Symbol

CD3E

NCBI Official Name

CD3e molecule, epsilon (CD3-TCR complex)

NCBI Organism

Homo sapiens

Background Reference 01

Van Dongen, J. J., Krissansen, G. W., Wolvers-Tettero, I. L., Comans-Bitter, W. M., Adriaansen, H. J., Hooijkaas, H., ... Terhorst, C. (1988) . Cytoplasmic expression of the CD3 antigen as a diagnostic marker for immature T-cell malignancies.Blood,71 (3), 603-612.

Background Reference 02

Haynes, B. F. (1986) . Summary of T cell studies performed during the second international workshop and conference on human leukocyte differentiation antigens. InLeukocyte typing II (pp. 3-30) . Springer New York.

Background Reference 03

Kap, Y. S., van Meurs, M., van Driel, N., Koopman, G., Melief, M. J., Brok, H. P., ... A't Hart, B. (2009) . A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.Journal of Histochemistry Cytochemistry,57 (12), 1159-1167.