CD3 Antibody [G4.18]
Product Specifications
Background
The G4.18 monoclonal antibody specifically reacts with rat CD3, a T cell lineage marker and associated with the T cell receptor (TCR) . CD3 is involved in antigen recognition, cell activation, and signal transduction and is found on subsets of NK-T, peripheral T, dendritic epidermal T, and thymocyte cells. Immobilized G4.18 antibody activates T cells in vitro and in vivo treatments of the G4.18 antibody prevents cardiac and skin allograft rejection.
NCBI Gene ID
25710
Swiss Prot
P19377
Host
Mouse
Reactivity
Rat
Clonality
Monoclonal
Clone
G4.18
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-235
Fragment
Mouse IgG3, kappa
Specificity
The G4.18 monoclonal antibody specifically reacts with rat CD3, a T cell lineage marker and associated with the T cell receptor (TCR) .
Symbol
Cd3d
NCBI Official Name
CD3 molecule, delta
NCBI Organism
Rattus norvegicus
Background Reference 01
Nicolls, M. R., Aversa, G. G., Pearce, N. W., Spinelli, A., Berger, M. F., Gurley, K. E., Hall, B. M. (1993) . Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody.Transplantation,55 (3), 459-468.
Background Reference 02
Morris, D. L., Komocsar, W. J. (1997) . Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats.Journal of pharmacological and toxicological methods,37 (1), 37-46.
Background Reference 03
Tran, G. T., Carter, N., He, X. Y., Spicer, T. S., Plain, K. M., Nicolls, M., ... Hodgkinson, S. J. (2001) . Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on Th1 cells that is augmented by IL-4.International immunology,13 (9), 1109-1120.
Other Product Names
Cd3d, Cd3d
Tested Applications
Flow, IHC, Functional Assays
Physical Properties
Liquid
Curated Selection
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