CD3 Antibody [17A2]

The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains gamma, delta, and epsilon subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 epsilon chain.

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation.

Miescher, G. C., Schreyer, M., MacDonald, H. R. (1989) . Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex.Immunology letters,23 (2), 113-118.

Mysliwietz, J., Thierfelder, S. (1992) . Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient.Blood,80 (10), 2661-2667.

Wu, L., Antica, M., Johnson, G. R., Scollay, R., Shortman, K. (1991) . Developmental potential of the earliest precursor cells from the adult mouse thymus.The Journal of experimental medicine,174 (6), 1617-1627.