CD62L Antibody [DREG-56]
Product Specifications
Background
The DREG-56 monoclonal antibody specifically reacts with human CD62L, also known as L-selectin and LECAM-1. It mediates the migration of lymphocytes to the site of inflammation and their return to the peripheral lymphoid tissues and to the HEV (high endothelial venules) . CD62L is expressed on monocytes, NK cells, neutrophils, granulocytes, and subsets of T and B cells. It is reported that the DREG-56 antibody inhibits the binding of lymphocytes to HEV tissue in frozen peripheral tissue.
NCBI Gene ID
6402
Swiss Prot
P14151
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
DREG-56
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-212
Fragment
Mouse IgG1, kappa
Specificity
The DREG-56 monoclonal antibody specifically reacts with human CD62L, also known as L-selectin and LECAM-1.
Symbol
SELL
NCBI Official Name
Selectin L
NCBI Organism
Homo sapiens
Background Reference 01
Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
Background Reference 02
Kishimoto, T. K., Jutila, M. A., Butcher, E. C. (1990) . Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule.Proceedings of the National Academy of Sciences,87 (6), 2244-2248.
Background Reference 03
Kishimoto, T. K., Warnock, R. A., Jutila, M. A., Butcher, E. C., Lane, C., Anderson, D. C., Smith, C. W. (1991) . Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro.Blood,78 (3), 805-811.
Other Product Names
TQ1, LAM1, LEU8, LNHR, LSEL, CD62L, LYAM1, PLNHR, LECAM1, SELL
Tested Applications
Flow, Functional Assays
Physical Properties
Liquid
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