CD62P Antibody [Psel.KO2.3] (PE)

Product Specifications

Background

The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140) . Upon activation it is quickly transported to the plasma membrane from the alpha-granules of platelets and WEibel-Palade bodies of endothelial cells. It is essential to the functions of cell adhesion during inflammatory reactions and in the interaction of platelets with monocytes and neutrophils. The Psel.KO2.3 antibody does not block adhesion and binds to an epitope common to several species including mouse, human, and rat.

NCBI Gene ID

6403;20344

Swiss Prot

P16109; P18337

Host

Mouse

Reactivity

Human, Mouse

Clonality

Monoclonal

Clone

Psel.KO2.3

Conjugation

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140) .

Symbol

SELP

NCBI Official Name

Selectin P (granule membrane protein 140kDa, antigen CD62)

NCBI Organism

Homo sapiens; Mus musculus

Background Reference 01

Massaguer, A., Engel, P., Prez‐del‐Pulgar, S., Bosch, J., Pizcueta, P. (2000) . Production and characterization of monoclonal antibodies against conserved epitopes of P‐selectin (CD62P) .Tissue antigens,56 (2), 117-128.

Background Reference 02

Kansas, G. S. (1996) . Selectins and their ligands: current concepts and controversies.Blood,88 (9), 3259-3287.

Background Reference 03

Bullard, D. C., Kunkel, E. J., Kubo, H., Hicks, M. J., Lorenzo, I., Doyle, N. A., ... Beaudet, A. L. (1996) . Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice.The Journal of experimental medicine,183 (5), 2329-2336.