CD62P Antibody [AK-4] (PE)
Product Specifications
Background
The AK-4 monoclonal antibody specifically reacts with human CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as platelet activation-dependent granule membrane protein (PADGEM) . Upon activation it is quickly transported to the plasma membrane from the alpha-granules of platelets and WEibel-Palade bodies of endothelial cells. It is essential to the functions of cell adhesion during inflammatory reactions and in the interaction of platelets with monocytes and neutrophils.
NCBI Gene ID
6403
Swiss Prot
P16109
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
AK-4
Conjugation
PE
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-198
Fragment
Mouse IgG1, kappa
Specificity
The AK-4 monoclonal antibody specifically reacts with human CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as platelet activation-dependent granule membrane protein (PADGEM) .
Symbol
SELP
NCBI Official Name
Selectin P (granule membrane protein 140kDa, antigen CD62)
NCBI Organism
Homo sapiens
Background Reference 01
Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.
Background Reference 02
Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
Background Reference 03
Johnson-Tidey, R. R., McGregor, J. L., Taylor, P. R., Poston, R. N. (1994) . Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1.The American journal of pathology,144 (5), 952.
Other Product Names
CD62, GRMP, PSEL, CD62P, GMP140, LECAM3, PADGEM, SELP
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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