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CD62P Antibody [AK-4] (PE)

Product Specifications

Background

The AK-4 monoclonal antibody specifically reacts with human CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as platelet activation-dependent granule membrane protein (PADGEM) . Upon activation it is quickly transported to the plasma membrane from the alpha-granules of platelets and WEibel-Palade bodies of endothelial cells. It is essential to the functions of cell adhesion during inflammatory reactions and in the interaction of platelets with monocytes and neutrophils.

NCBI Gene ID

6403

Swiss Prot

P16109

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

AK-4

Conjugation

PE

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The AK-4 monoclonal antibody specifically reacts with human CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as platelet activation-dependent granule membrane protein (PADGEM) .

Symbol

SELP

NCBI Official Name

Selectin P (granule membrane protein 140kDa, antigen CD62)

NCBI Organism

Homo sapiens

Background Reference 01

Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.

Background Reference 02

Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

Background Reference 03

Johnson-Tidey, R. R., McGregor, J. L., Taylor, P. R., Poston, R. N. (1994) . Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1.The American journal of pathology,144 (5), 952.

Other Product Names

CD62, GRMP, PSEL, CD62P, GMP140, LECAM3, PADGEM, SELP

Tested Applications

Flow

Physical Properties

Liquid

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