CD2 Antibody [RM2-5]
Product Specifications
Background
The RM2-5 monoclonal antibody specifically binds to mouse CD2, a member of the Ig superfamily and type I transmembrane glycoprotein. CD2 is expressed on B cells, T cells, NK cells, and thymocytes and its ligand is CD48. It may be involved in immunoregulation, thymocyte maturation, and T-cell activation. The RM2-5 antibody has been reported to block CD2 mediated cell to cell adhesion.
NCBI Gene ID
12481
Swiss Prot
P08920
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
RM2-5
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-187
Fragment
Rat IgG2b, lambda
Specificity
The RM2-5 monoclonal antibody specifically binds to mouse CD2, a member of the Ig superfamily and type I transmembrane glycoprotein.
Symbol
Cd2
NCBI Official Name
CD2 antigen
NCBI Organism
Mus musculus
Background Reference 01
Yagita, H., Nakamura, T., Karasuyama, H., Okumura, K. (1989) . Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.Proceedings of the National Academy of Sciences,86 (2), 645-649.
Background Reference 02
Nakamura, T. E. T. S. U. Y. A., Takahashi, K. A. Z. U. H. I. S. A., Fukazawa, T. O. H. R. U., Koyanagi, M. A. K. O. T. O., Yokoyama, A., Kato, H., ... Okumura, K. (1990) . Relative contribution of CD2 and LFA-1 to murine T and natural killer cell functions.The Journal of Immunology,145 (11), 3628-3634.
Background Reference 03
Kato, K., Koyanagi, M., Okada, H., Takanashi, T., Wong, Y. W., Williams, A. F., ... Yagita, H. (1992) . CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.The Journal of experimental medicine,176 (5), 1241-1249.
Other Product Names
Ly37, LFA-2, Ly-37, Cd2
Tested Applications
Flow
Physical Properties
Liquid
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