CD2 Antibody [RM2-5]

Product Specifications

Background

The RM2-5 monoclonal antibody specifically binds to mouse CD2, a member of the Ig superfamily and type I transmembrane glycoprotein. CD2 is expressed on B cells, T cells, NK cells, and thymocytes and its ligand is CD48. It may be involved in immunoregulation, thymocyte maturation, and T-cell activation. The RM2-5 antibody has been reported to block CD2 mediated cell to cell adhesion.

NCBI Gene ID

12481

Swiss Prot

P08920

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

RM2-5

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Rat IgG2b, lambda

Specificity

The RM2-5 monoclonal antibody specifically binds to mouse CD2, a member of the Ig superfamily and type I transmembrane glycoprotein.

Symbol

Cd2

NCBI Official Name

CD2 antigen

NCBI Organism

Mus musculus

Background Reference 01

Yagita, H., Nakamura, T., Karasuyama, H., Okumura, K. (1989) . Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.Proceedings of the National Academy of Sciences,86 (2), 645-649.

Background Reference 02

Nakamura, T. E. T. S. U. Y. A., Takahashi, K. A. Z. U. H. I. S. A., Fukazawa, T. O. H. R. U., Koyanagi, M. A. K. O. T. O., Yokoyama, A., Kato, H., ... Okumura, K. (1990) . Relative contribution of CD2 and LFA-1 to murine T and natural killer cell functions.The Journal of Immunology,145 (11), 3628-3634.

Background Reference 03

Kato, K., Koyanagi, M., Okada, H., Takanashi, T., Wong, Y. W., Williams, A. F., ... Yagita, H. (1992) . CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.The Journal of experimental medicine,176 (5), 1241-1249.