CD2 Antibody [RPA-2.10]

Product Specifications

Background

The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein. CD2 is expressed on NK cells, thymocytes, T lymphocytes, and B cell subsets. CD2 is involved in cell-cell adhesion, T cell activation, and T cell signaling. Its ligand is CD58 and it is reported to bind to CD48, CD59, and CD15. The RPA-2.10 antibody is reported to be cross-reactive with pigs and non-human primates..

NCBI Gene ID

914

Swiss Prot

P06729

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

RPA-2.10

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein.

Symbol

CD2

NCBI Official Name

CD2 molecule

NCBI Organism

Homo sapiens

Background Reference 01

Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Background Reference 02

Hahn, W. C., Burakoff, S. J., Bierer, B. E. (1993) . Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58.The Journal of Immunology,150 (7), 2607-2619.

Background Reference 03

Aversa, G. G., Bishop, G. A., Suranyi, M. G., Hall, B. M. (1987, February) . RPA-2.10: an anti-CD2 monoclonal antibody that inhibits alloimmune responses and monitors T cell activation. InTransplantation proceedings (Vol. 19, No. 1 Pt 1, pp. 277-278) .