CD61 Antibody [2C9.G3]

Product Specifications

Background

The 2C9.G3 monoclonal antibody specifically reacts with the mouse/rat CD61 molecule, known as the integrin beta 3 that forms the vitronectin receptor with CD51. The complex binds to other ligands such as fibrinogen, fibronectin, thrombospondin, and von WIllebrand factor. It is expressed by granulocytes, platelets, activated T cells, smooth muscle, and a subset of B cells.

NCBI Gene ID

16416

Swiss Prot

O54890

Host

Hamster

Reactivity

Mouse, Rat

Clonality

Monoclonal

Clone

2C9.G3

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Armenian Hamster IgG

Specificity

The 2C9.G3 monoclonal antibody specifically reacts with the mouse/rat CD61 molecule, known as the integrin beta 3 that forms the vitronectin receptor with CD51.

Symbol

Itgb3

NCBI Official Name

Integrin beta 3

NCBI Organism

Mus musculus

Background Reference 01

Vaillant, F., Asselin-Labat, M. L., Shackleton, M., Forrest, N. C., Lindeman, G. J., Visvader, J. E. (2008) . The mammary progenitor marker CD61/-beta 3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis.Cancer research,68 (19), 7711-7717.

Background Reference 02

Yasuda, M., Hasunuma, Y., Adachi, H., Sekine, C., Sakanishi, T., Hashimoto, H., ... Okumura, K. (1995) . Expression and function of fibronectin binding integrins on rat mast cells.International immunology,7 (2), 251-258.

Background Reference 03

Wu, X., Mogford, J. E., Platts, S. H., Davis, G. E., Meininger, G. A., Davis, M. J. (1998) . Modulation of calcium current in arteriolar smooth muscle by alpha v-beta 3 and alpha 5-beta 1 integrin ligands.The Journal of cell biology,143 (1), 241-252.