CD61 Antibody [VI-PL2] (PE)

Product Specifications

Background

The VI-PL2 monoclonal antibody reacts with CD61, a type I integral transmembrane glycoprotein also known as integrin beta 3. CD61 forms a complex with CD41 (platelet gpIIb) and CD51 (integrin alphaV) . It is expressed on osteoclasts, fibroblasts, platelets, macrophages, and megakaryocytes and appears to bind to fibronectin, vitronectin, thrombospondin, and fibrinogen and vWF. The VI-PL2 antibody is reported to be cross-reactive with baboon, rhesus, and cynomolgus.

NCBI Gene ID

3690

Swiss Prot

P05106

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

VI-PL2

Conjugation

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The VI-PL2 monoclonal antibody reacts with CD61, a type I integral transmembrane glycoprotein also known as integrin beta 3.

Symbol

ITGB3

NCBI Official Name

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

NCBI Organism

Homo sapiens

Background Reference 01

Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.

Background Reference 02

Barrett, L., Dai, C., Gamberg, J., Gallant, M., Grant, M. (2007) . Circulating CD14 CD36+ peripheral blood mononuclear cells constitutively produce interleukin-10.Journal of leukocyte biology,82 (1), 152-160.

Background Reference 03

Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.