CD51/CD61 Antibody [23C6]
Product Specifications
Background
The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor. The complex binds to other ligands such as CD29, fibrinogen, fibrinectin, vWf, laminin, and thrombospondin. It is expressed by endothelial cells, osteoclasts, melanoma cells, and at low levels on platelets and macrophages. The 23C6 antibody is reported to be able to block the receptors ability to form interactions with some of its ligands.
NCBI Gene ID
3685;3690
Swiss Prot
P06756; P05106
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
23C6
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Fragment
Mouse IgG1, kappa
Specificity
The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor.
Symbol
ITGAV; ITGB3
NCBI Official Name
Integrin, alpha V; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
NCBI Organism
Homo sapiens
Background Reference 01
Horton, M. A., Lewis, D., McNulty, K., Pringle, J. A., Chambers, T. J. (1985) . Monoclonal antibodies to osteoclastomas (giant cell bone tumors) : definition of osteoclast-specific cellular antigens.Cancer research,45 (11 Part 2), 5663-5669.
Background Reference 02
Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Background Reference 03
Chuntharapai, A., Bodary, S., Horton, M., Kim, K. J. (1993) . Blocking monoclonal antibodies to alpha v-beta 3 integrin: A unique epitope of alpha v-beta 3 integrin is present on human osteoclasts.Experimental cell research,205 (2), 345-352.
Other Product Names
CD51, MSK8, VNRA, VTNR, GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, ITGAV, ITGB3
Tested Applications
Flow, Functional Assays
Physical Properties
Liquid
Curated Selection
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