CD41 Antibody [MWReg30] (FITC)

Product Specifications

Background

The MWReg30 monoclonal antibody specifically reacts with mouse CD41, a transmembrane glycoprotein also known as integrin alpha 2b GPIIb. It is expressed on hematopoietic progenitors, megakaryocytes, and platelets. It forms a receptor with CD61 (integrin beta 3) that binds adhesion molecules such as fibrinogen, fibronectin, von Willebrand factor, and thrombin. Defects or absence of CD41 has been found to lead to coagulation disorders. The expression profile of CD150+, CD48-, and CD41- can be used to identify hematopoietic stem cells.

NCBI Gene ID

16399

Swiss Prot

Q9QUM0

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

MWReg30

Conjugation

FITC

Type

Primary Antibodies

Field of Research

Other

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG1, kappa

Specificity

The MWReg30 monoclonal antibody specifically reacts with mouse CD41, a transmembrane glycoprotein also known as integrin alpha 2b GPIIb.

Symbol

Itga2b

NCBI Official Name

Integrin alpha 2b

NCBI Organism

Mus musculus

Background Reference 01

Schmidt, R. E., Grau, G. E., M, D. N., Nieswandt, B., Echtenacher, B., Wachs, F. P., ... Gessner, J. E. (1999) . Acute Systemic Reaction and Lung Alterations Induced by an Antiplatelet.Blood,94 (2), 684-693.

Background Reference 02

Bertrand, J. Y., Giroux, S., Golub, R., Klaine, M., Jalil, A., Boucontet, L., ... Cumano, A. (2005) . Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin.Proceedings of the National Academy of Sciences of the United States of America,102 (1), 134-139.

Background Reference 03

Mitjavila-Garcia, M. T., Cailleret, M., Godin, I., Nogueira, M. M., Cohen-Solal, K., Schiavon, V., ... Vainchenker, W. (2002) . Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells.Development,129 (8), 2003-2013.