CD31 Antibody [390]

Product Specifications

Background

The 390 monoclonal antibody specifically reacts with mouse cd31, a 130-140 kDA type I transmembrane glycoprotein also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) . CD31 is reported to bind to CD38 and is expressed on platelets, monocytes, granulocytes, and endothelial cells. It plays a role in angiogenesis, wound healing, cellular migration, and signal transduction.

NCBI Gene ID

18613

Swiss Prot

Q08481

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

390

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Cancer

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Rat IgG2a, kappa

Specificity

The 390 monoclonal antibody specifically reacts with mouse cd31, a 130-140 kDA type I transmembrane glycoprotein also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) .

Symbol

Pecam1

NCBI Official Name

Platelet/endothelial cell adhesion molecule 1

NCBI Organism

Mus musculus

Background Reference 01

HORENSTEIN, A., STOCKINGER, H., Imhof, B., MALAVASI, F. (1998) . CD38 binding to human myeloid cells is mediated by mouse and human CD31.Biochem. J,330, 1129-1135.

Background Reference 02

Baldwin, H. S., Shen, H. M., Yan, H. C., DeLisser, H. M., Chung, A., Mickanin, C., ... Albelda, S. M. (1994) . Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) : alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development.Development,120 (9), 2539-2553.

Background Reference 03

DeLisser, H. M., Christofidou-Solomidou, M., Strieter, R. M., Burdick, M. D., Robinson, C. S., Wexler, R. S., ... Albelda, S. M. (1997) . Involvement of endothelial PECAM-1/CD31 in angiogenesis.The American journal of pathology,151 (3), 671.