CD31 Antibody [WM59]
Product Specifications
Background
The WM59 monoclonal antibody specifically reacts with human CD31, a 130-140 kDA type I transmembrane glycoprotein also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) or Endocam. CD31 is reported to bind to CD38 and is expressed on platelets, monocytes, granulocytes, and endothelial cells. It plays a role in angiogenesis, wound healing, cellular migration, and signal transduction.
NCBI Gene ID
5175
Swiss Prot
P16284
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
WM59
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Cancer
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Fragment
Mouse IgG1, kappa
Specificity
The WM59 monoclonal antibody specifically reacts with human CD31, a 130-140 kDA type I transmembrane glycoprotein also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) or Endocam.
Symbol
PECAM1
NCBI Official Name
Platelet/endothelial cell adhesion molecule 1
NCBI Organism
Homo sapiens
Background Reference 01
Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
Background Reference 02
Porat, Y., Porozov, S., Belkin, D., Shimoni, D., Fisher, Y., Belleli, A., ... Savion, N. (2006) . Isolation of an adult blood‐derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages.British journal of haematology,135 (5), 703-714.
Background Reference 03
Vaporciyan, A. A., DeLisser, H. M., Yan, H. C., Jones, M. L., Ward, P. A., Albelda, S. M. (1993) . Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo.Science,262 (5139), 1580-1582.
Other Product Names
CD31, PECA1, GPIIA', PECAM-1, endoCAM, CD31/EndoCAM, PECAM1
Tested Applications
Flow, Functional Assays
Physical Properties
Liquid
Frequently Asked Questions
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