CD21 Antibody [HB5] (FITC)

Product Specifications

Background

The HB5 monoclonal antibody specifically reacts with human CD21, a 145 kDA glycosylated type I integral membrane protein. CD21 is reported to be involved in B cell activation and proliferation. It is expressed on follicular dendritic cells, mature B cells, a subset of T cells, and a subset of epithelial cells. It is the receptor utilized by the Epstein-Barr virus to infect B cells.

NCBI Gene ID

1380

Swiss Prot

P20023

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

HB5

Conjugation

FITC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG2a, kappa

Specificity

The HB5 monoclonal antibody specifically reacts with human CD21, a 145 kDA glycosylated type I integral membrane protein.

Symbol

CR2

NCBI Official Name

Complement component (3d/Epstein Barr virus) receptor 2

NCBI Organism

Homo sapiens

Background Reference 01

Tedder, T. F., Clement, L. T., Cooper, M. D. (1984) . Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody.The Journal of Immunology,133 (2), 678-683.

Background Reference 02

Fingeroth, J. D., Weis, J. J., Tedder, T. F., Strominger, J. L., Biro, P. A., Fearon, D. T. (1984) . Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.Proceedings of the National Academy of Sciences,81 (14), 4510-4514.

Background Reference 03

Nemerow, G. R., Wolfert, R. O. B. E. R. T., McNaughton, M. E., Cooper, N. R. (1985) . Identification and characterization of the Epstein-Barr virus receptor on human B lymphocytes and its relationship to the C3d complement receptor (CR2) .Journal of virology,55 (2), 347-351.