CD11a Antibody [M17/4]
Product Specifications
Background
The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein. CD11a is the integrin alpha L chain that forms with CD18 the heterodimer molecule Lymphocyte Function-associated Antigen-1 (LFA-1) . LFA-1 is expressed on all leukocytes and is involved in intercellular adhesions. The M17/4 antibody blocks many of the LFA-1 mediated cell interaction and in vivo it prolongs allograft survival, inhibits the autoimmune response, and reduces graft versus host reactions.
NCBI Gene ID
16408
Swiss Prot
P24063
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
M17/4
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Cancer
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-138
Fragment
Rat IgG2a, kappa
Specificity
The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein.
Symbol
Itgal
NCBI Official Name
Integrin alpha L
NCBI Organism
Mus musculus
Background Reference 01
Saban, M. R., Saban, R., Bjorling, D., Haak-Frendscho, M. (1997) . Involvement of leukotrienes, TNF-alpha, and the LFA-1/ICAM-1 interaction in substance P-induced granulocyte infiltration.Journal of leukocyte biology,61 (4), 445-451.
Background Reference 02
Zhao, Y., Iwata, M. (1995) . Cross-linking of the TCRCD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: the signal is canceled by FK506.International immunology,7 (9), 1387-1396.
Background Reference 03
Kootstra, C. J., Van Der Giezen, D. M., Van Krieken, J. H. J. M., De Heer, E., Bruijn, J. A. (1997) . Effective treatment of experimental lupus nephritis by combined administration of anti‐CD11a and anti‐CD54 antibodies.Clinical Experimental Immunology,108 (2), 324-332.
Other Product Names
Cd11a, LFA-1, Ly-15, Ly-21, (p180), LFA-1A, Itgal
Tested Applications
Flow, Functional Assays
Physical Properties
Liquid
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