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CD11b Antibody [M1/70]

Product Specifications

Background

The M1/70 monoclonal antibody specifically reacts with the 170 kDa alphaM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18) . Mac-1 binds to C3bi, CD54 (ICAM-1), and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.

NCBI Gene ID

3684

Swiss Prot

P11215

Host

Rat

Reactivity

Human, Mouse

Clonality

Monoclonal

Clone

M1/70

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=76-116

Fragment

Rat IgG2b, kappa

Specificity

The M1/70 monoclonal antibody specifically reacts with the 170 kDa alphaM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18) .

Symbol

ITGAM

NCBI Official Name

Integrin, alpha M (complement component 3 receptor 3 subunit)

NCBI Organism

Homo sapiens

Background Reference 01

Sanchez-Madrid, F., Simon, P., Thompson, S., Springer, T. A. (1983) . Mapping of antigenic and functional epitopes on the alpha-and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1.The Journal of experimental medicine,158 (2), 586-602.

Background Reference 02

Ault, K. A., Springer, T. A. (1981) . Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells.The Journal of Immunology,126 (1), 359-364.

Background Reference 03

Springer, T., Galfre, G., Secher, D. S., Milstein, C. (1978) . Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens.European journal of immunology,8 (8), 539-551.

Other Product Names

CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM

Tested Applications

Flow, Functional Assays, IHC, IF, IP

Physical Properties

Liquid

Curated Selection

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