CD11c Antibody [N418] (APC)
Product Specifications
Background
The N418 monoclonal antibody specifically reacts with the integrin alphax chain of the mouse CD11c, which is expressed on dendritic cells, CD4-/CD8+ intestinal intraepithelial lymphocytes (IEL) and some activated T lymphocytes. Low levels of CD11c were detected on mouse splenic natural killer cells and on the monocyte/macrophage lineage cells.CD11c expression is upregulated on IEL and T lymphocytes after activation. It binds to CD54, fibrinogen and iC3b and influences the leukocyte adhesive interactions. The N418 antibody binds to CD11c on splenic dendritic cells of the mouse in the T-dependent areas. It also contributes to the binding of iC3b.
NCBI Gene ID
16411
Swiss Prot
Q9QXH4
Host
Hamster
Reactivity
Mouse
Clonality
Monoclonal
Clone
N418
Conjugation
APC
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-112
Fragment
Armenian Hamster IgG
Specificity
The N418 monoclonal antibody specifically reacts with the integrin alphax chain of the mouse CD11c, which is expressed on dendritic cells, CD4-/CD8+ intestinal intraepithelial lymphocytes (IEL) and some activated T lymphocytes.
Symbol
Itgax
NCBI Official Name
Integrin alpha X
NCBI Organism
Mus musculus
Background Reference 01
Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., van der Merwe, P. A. (1997) .The leucocyte antigen factsbook. Academic Press.
Background Reference 02
Pulendran, B., Lingappa, J., Kennedy, M. K., Smith, J., Teepe, M., Rudensky, A., ... Maraskovsky, E. (1997) . Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice.The Journal of Immunology,159 (5), 2222-2231.
Background Reference 03
Xin, K. Q., Mizukami, H., Urabe, M., Toda, Y., Shinoda, K., Yoshida, A., ... Okuda, K. (2006) . Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.Journal of virology,80 (24), 11899-11910.
Other Product Names
Cr4, N418, Cd11c, AI449405, Itgax
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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