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CD11b Antibody [ICRF44] (APC)

Product Specifications

Background

The ICRF44 monoclonal antibody specifically reacts with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin beta2) a complex known as Mac-1. CD11b is expressed on the surface of activated lymphocytes, a subset of natural killer cells, granulocytes, and monocytes. It functions as a receptor in cell-cell and cell-matrix interactions and as a receptor for iC3b, ICAM-1, ICAM-2, and ICAM-3 intercellular adhesion molecules.

NCBI Gene ID

3684

Swiss Prot

P11215

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

ICRF44

Conjugation

APC

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=76-095

Fragment

Mouse IgG1, kappa

Specificity

The ICRF44 monoclonal antibody specifically reacts with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin beta2) a complex known as Mac-1.

Symbol

ITGAM

NCBI Official Name

Integrin, alpha M (complement component 3 receptor 3 subunit)

NCBI Organism

Homo sapiens

Background Reference 01

Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., van der Merwe, P. A. (1997) .The leucocyte antigen factsbook. Academic Press.

Background Reference 02

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Background Reference 03

Sotiriou, S. N., Orlova, V. V., Al-Fakhri, N., Ihanus, E., Economopoulou, M., Isermann, B., ... Chavakis, T. (2006) . Lipoprotein (a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin.The FASEB journal,20 (3), 559-561.

Other Product Names

CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM

Tested Applications

Flow

Physical Properties

Liquid

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