CD90.2 Antibody [30-H12] (APC)

Product Specifications

Background

The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma.The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.

NCBI Gene ID

21838

Swiss Prot

P01831

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

30-H12

Conjugation

APC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2b

Specificity

The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.

Symbol

Thy1

NCBI Official Name

Thymus cell antigen 1, theta

NCBI Organism

Mus musculus

Background Reference 01

Ledbetter, J. A., Herzenberg, L. A. (1979) . Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*.Immunological reviews,47 (1), 63-90.

Background Reference 02

Radrizzani, M., Carminatti, H., Pivetta, O. H., Vargas, V. P. (1995) . Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum.Journal of neuroscience research,42 (2), 220-227.

Background Reference 03

Seaman, W. E., Wofsy, D., Greenspan, J. S., Ledbetter, J. A. (1983) . Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.The Journal of Immunology,130 (4), 1713-1718.