CD80 Antibody [2D10.4] (PE)
Product Specifications
Background
The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR) . CD28 also binds a second B7 ligand known as CD86 (B7-2) . Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
NCBI Gene ID
941
Swiss Prot
P33681
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
2D10.4
Conjugation
PE
Type
Primary Antibodies
Field of Research
Innate Immunity, Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-039
Fragment
Mouse IgG1, kappa
Specificity
The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR) .
Symbol
CD80
NCBI Official Name
CD80 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.
Background Reference 02
Cognasse, F., Hamzeh‐Cognasse, H., Lafarge, S., Chavarin, P., Pozzetto, B., Richard, Y., Garraud, O. (2008) . Identification of two subpopulations of purified human blood B cells, CD27 CD23+ and CD27high CD80+, that strongly express cell surface Toll‐like receptor 9 and secrete high levels of interleukin‐6.Immunology,125 (3), 430-437.
Background Reference 03
Bashuda, H., Kimikawa, M., Seino, K., Kato, Y., Ono, F., Shimizu, A., ... Okumura, K. (2005) . Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates.Journal of Clinical Investigation,115 (7), 1896-1902.
Other Product Names
B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1, CD80
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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