CD70 Antibody [FR70]
Product Specifications
Background
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.
NCBI Gene ID
21948
Swiss Prot
O55237
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
FR70
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-031
Fragment
Rat IgG2b, kappa
Specificity
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily.
Symbol
Cd70
NCBI Official Name
CD70 antigen
NCBI Organism
Mus musculus
Background Reference 01
Tesselaar, K., Gravestein, L. A., Van Schijndel, G. M., Borst, J., Van Lier, R. A. (1997) . Characterization of murine CD70, the ligand of the TNF receptor family member CD27.The Journal of Immunology,159 (10), 4959-4965.
Background Reference 02
Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., ... Okumura, K. (1998) . Characterization of murine CD70 by molecular cloning and mAb.International immunology,10 (4), 517-526.
Background Reference 03
Bullock, T. N., Yagita, H. (2005) . Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.The Journal of Immunology,174 (2), 710-717.
Other Product Names
Cd27l, CD27LG, Tnfsf7, Cd70
Tested Applications
Flow, Functional Assays
Physical Properties
Liquid
Curated Selection
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