CD70 Antibody [FR70]

Product Specifications

Background

The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.

NCBI Gene ID

21948

Swiss Prot

O55237

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

FR70

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Rat IgG2b, kappa

Specificity

The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily.

Symbol

Cd70

NCBI Official Name

CD70 antigen

NCBI Organism

Mus musculus

Background Reference 01

Tesselaar, K., Gravestein, L. A., Van Schijndel, G. M., Borst, J., Van Lier, R. A. (1997) . Characterization of murine CD70, the ligand of the TNF receptor family member CD27.The Journal of Immunology,159 (10), 4959-4965.

Background Reference 02

Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., ... Okumura, K. (1998) . Characterization of murine CD70 by molecular cloning and mAb.International immunology,10 (4), 517-526.

Background Reference 03

Bullock, T. N., Yagita, H. (2005) . Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.The Journal of Immunology,174 (2), 710-717.