CD40 Antibody [HM40-3]
Product Specifications
Background
The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The HM40-3 antibody blocks the binding of CD40L (CD154) and stimulates B and dendritic cell proliferation.
NCBI Gene ID
21939
Swiss Prot
P27512
Host
Hamster
Reactivity
Mouse, Rat
Clonality
Monoclonal
Clone
HM40-3
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-025
Fragment
Armenian Hamster IgM, kappa
Specificity
The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50.
Symbol
Cd40
NCBI Official Name
CD40 antigen
NCBI Organism
Mus musculus
Background Reference 01
Kaneko, Y., Hirose, S., Abe, M., Yagita, H., Okumura, K., Shirai, T. (1996) . CD40‐mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus.European journal of immunology,26 (12), 3061-3065.
Background Reference 02
Ferlin, W. G., Severinson, E., Strm, L., Heath, A. W., Coffman, R. L., Ferrick, D. A., Howard, M. C. (1996) . CD40 signaling induces interleukin‐4‐independent IgE switching in vivo.European journal of immunology,26 (12), 2911-2915.
Background Reference 03
Kashiwada, M., Kaneko, Y., Yagita, H., Okumura, K., Takemori, T. (1996) . Activation of mitogen‐activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells.European journal of immunology,26 (7), 1451-1458.
Other Product Names
IGM, p50, Bp50, GP39, IMD3, TRAP, HIGM1, T-BAM, Tnfrsf5, AI326936, Cd40
Tested Applications
Flow, Functional Assays
Physical Properties
Liquid
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