CD40 Antibody [5C3]
Product Specifications
Background
The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154) . In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation.
NCBI Gene ID
958
Swiss Prot
P25942
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
5C3
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-020
Fragment
Mouse IgG1, kappa
Specificity
The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein.
Symbol
CD40
NCBI Official Name
CD40 molecule, TNF receptor superfamily member 5
NCBI Organism
Homo sapiens
Background Reference 01
Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
Background Reference 02
Barclay, A. N., Birkeland, M. L., Brown, M. H., Beyers, A. D., David, S. J., Somoza, C., Williams, A. F. The Leukocyte Antigen Facts Book. 1993.Academic Prss, London.
Background Reference 03
Challa, A., Pound, J. D., Gordon, J., Armitage, R. J. (1999) . Epitope‐dependent synergism and antagonism between CD40 antibodies and soluble CD40 ligand for the regulation of CD23 expression and IgE synthesis in human B cells.Allergy,54 (6), 576-583.
Other Product Names
P50, Bp50, CDW40, TNFRSF5, CD40
Tested Applications
Flow, Functional Assays
Physical Properties
Liquid
Curated Selection
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