CD30 Antibody [mCD30.1]

Product Specifications

Background

The mCD301 monoclonal antibody specifically binds to mouse CD30, a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily. It is expressed on activated T, B, NK, and monocyte cells. Its expression on activated T lymphocytes is regulated by cytokines and CD28. The ligand for CD30 is CD153. It has been suggested that the molecule plays a role in the protection against autoimmunity and the regulation of Th1 and Th2 cytokine secretion.

NCBI Gene ID

21941

Swiss Prot

Q60846

Host

Hamster

Reactivity

Mouse

Clonality

Monoclonal

Clone

MCD30.1

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Apoptosis

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Armenian Hamster IgG

Specificity

The mCD301 monoclonal antibody specifically binds to mouse CD30, a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily.

Symbol

Tnfrsf8

NCBI Official Name

Tumor necrosis factor receptor superfamily, member 8

NCBI Organism

Mus musculus

Background Reference 01

Siegmund, T., Armitage, N., Wicker, L. S., Peterson, L. B., Todd, J. A., Lyons, P. A. (2000) . Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9. 2.Diabetes,49 (9), 1612-1616.

Background Reference 02

Falini, B., Pileri, S., Pizzolo, G., D, H., Flenghi, L., Stirpe, F., ... Stein, H. (1995) . CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy.BLOOD-NEW YORK-,85, 1-1.

Background Reference 03

Heath, W. R., Kurts, C., Caminschi, I., Carbone, F. R., Miller, J. F. (1999) . CD 30 prevents T‐cell responses to non‐lymphoid tissues.Immunological reviews,169 (1), 23-29.