CD30 Antibody [Ber-H2] (PE)

Product Specifications

Background

The Ber-H2 monoclonal antibody specifically reacts with human CD30, a 120kDA type I transmembrane glycoprotein of the tumor necrosis factor receptor superfamily (TNFR) also known as the Ki-1 antigen. CD30 can elicit signals leading to either activation or apoptosis through interaction with CD30 ligand (CD30L) . It is expressed by a subset of extrafollicular activated B and T cells, lung macrophages, activated NK cells, lymphomas, and endothelial cells. It is highly expressed on Hodgkins and Reed-Sternberg cells.

NCBI Gene ID

943

Swiss Prot

P28908

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

Ber-H2

Conjugation

Type

Primary Antibodies

Field of Research

Apoptosis

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The Ber-H2 monoclonal antibody specifically reacts with human CD30, a 120kDA type I transmembrane glycoprotein of the tumor necrosis factor receptor superfamily (TNFR) also known as the Ki-1 antigen.

Symbol

TNFRSF8

NCBI Official Name

Tumor necrosis factor receptor superfamily, member 8

NCBI Organism

Homo sapiens

Background Reference 01

Schwarting, R., Gerdes, J., Durkop, H., Falini, B., Pileri, S., Stein, H. (1989) . BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope.Blood,74 (5), 1678-1689.

Background Reference 02

Beljaards, R. C., Meijer, C. J., Scheffer, E., Toonstra, J., Van Vloten, W. A., Van Der Putte, S. C., ... Willemze, R. (1989) . Prognostic significance of CD30 (Ki-1/Ber-H2) expression in primary cutaneous large-cell lymphomas of T-cell origin. A clinicopathologic and immunohistochemical study in 20 patients.The American journal of pathology,135 (6), 1169.

Background Reference 03

Horie, R., Watanabe, T. (1998, December) . CD30: expression and function in health and disease. InSeminars in immunology (Vol. 10, No. 6, pp. 457-470) . Academic Press.