CD20 Antibody [AISB12]
Product Specifications
Background
The AISB12 monoclonal antibody specifically reacts with mouse cd20, a 32kDA B-lymphocyte surface molecule. CD20 is expressed by B cells in all stage of development, except for the initial pro-B and final plasma cells. CD20 has no natural ligands and has an important role in enabling B cells to respond optimally to T-independent antigens. The AISB12 antibody binds to the extracellular loop domain of the CD20 molecule.
NCBI Gene ID
12482
Swiss Prot
P19437
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
AISB12
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-010
Fragment
Rat IgG2a
Specificity
The AISB12 monoclonal antibody specifically reacts with mouse cd20, a 32kDA B-lymphocyte surface molecule.
Symbol
Ms4a1
NCBI Official Name
Membrane-spanning 4-domains, subfamily A, member 1
NCBI Organism
Mus musculus
Background Reference 01
Uchida, J., Hamaguchi, Y., Oliver, J. A., Ravetch, J. V., Poe, J. C., Haas, K. M., Tedder, T. F. (2004) . The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptordependent mechanisms during anti-CD20 antibody immunotherapy.The Journal of experimental medicine,199 (12), 1659-1669.
Background Reference 02
Uchida, J., Lee, Y., Hasegawa, M., Liang, Y., Bradney, A., Oliver, J. A., ... Tedder, T. F. (2004) . Mouse CD20 expression and function.International immunology,16 (1), 119-129.
Background Reference 03
Qian, J., Zheng, Y., Zheng, C., Wang, L., Qin, H., Hong, S., ... Yi, Q. (2012) . Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma.Blood,119 (1), 161-169.
Other Product Names
Cd20, Ly-44, Ms4a2, AA960661, Ms4a1
Tested Applications
Flow, Functional Assays
Physical Properties
Liquid
Curated Selection
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